2011-09-15
Lobophytones U – Z1, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum
Publication
Publication
Chemistry & Biodiversity , Volume 8 - Issue 9 p. 1724- 1734
Chemical examination of a Chinese soft coral Lobophytum pauciflorum resulted in the isolation of seven new biscembranoids named lobophytones U-Z(1) (1-7, resp.), together with methyl sartortuoate (8) and nyalolide (9). The structures of the new compounds were elucidated by 1D- and 2D-NMR (COSY, HSQC, HMBC, and NOESY) spectroscopic analysis in association with MS and IR data. All compounds were tested against lipopolysaccharide (LPS)-induced nitric oxide (NO) release in mouse peritoneal macrophage. Lobophytone Z (6) inhibited NO production with an IC(50) value of 2.6 μM. Lobophytone H (1) showed inhibitory activities against the bacteria S. aureus and S. pneumoniae.
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| doi.org/10.1002/cbdv.201000244 | |
| Chemistry & Biodiversity | |
| Organisation | Staff publications |
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Pengcheng Yan, Zhiwei Deng, Leen van Ofwegen, Peter Proksch& Wenhan Lin. (2011). Lobophytones U – Z1, Biscembranoids from the Chinese Soft Coral Lobophytum pauciflorum. Chemistry & Biodiversity, 8(9), 1724–1734.https://doi.org/10.1002/cbdv.201000244 |
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