2015-07-01
Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors
Publication
Publication
Bioorganic & Medicinal Chemistry Letters , Volume 25 - Issue 13 p. 2650- 2653
Two new strongylophorine derivatives, along with six known strongylophorines, were isolated from the marine sponge Petrosia corticata as proteasome inhibitors. Of these, a hemiacetal mixture of strongylophorines-13/-14 was the strongest inhibitor of the proteasome with an IC50 of 2.1 μM.
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| doi.org/10.1016/j.bmcl.2015.04.075 | |
| Bioorganic & Medicinal Chemistry Letters | |
| Organisation | Staff publications |
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Noda, Ai, Sakai, Eriko, Kato, Hikaru, Losung, Fitje, Mangindaan, Remy E.P., de Voogd, N., Yokosawa, Hideyoshi& Tsukamoto, Sachiko. (2015). Strongylophorines, meroditerpenoids from the marine sponge Petrosia corticata, function as proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters, 25(13), 2650–2653.https://doi.org/10.1016/j.bmcl.2015.04.075 |
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