2014-08-12
Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa
Publication
Publication
Natural Product Research , Volume 29 - Issue 3 p. 231- 238
Chemical investigation of methanolic extracts of the two Indonesian marine sponges Stylissa massa and Stylissa flabelliformis yielded 25 bromopyrrole alkaloids including 2 new metabolites. The structures of all isolated compounds were unambiguously elucidated based on extensive 1D and 2D NMR, LR-MS and HR-MS analyses. All isolated compounds were assayed for their antiproliferative and protein kinase inhibitory activities. Several of the tested compounds revealed selective activity(ies) which suggested preliminary SARs of the isolated bromopyrrole alkaloids.
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| doi.org/10.1080/14786419.2014.947496 | |
| Natural Product Research | |
| Organisation | Staff publications |
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Ebada, Sherif S., Linh, Mai Hoang, Longeon, Arlette, de Voogd, N., Durieu, Emilie, Meijer, Laurent, … Proksch, Peter. (2014). Dispacamide E and other bioactive bromopyrrole alkaloids from two Indonesian marine sponges of the genus Stylissa. Natural Product Research, 29(3), 231–238. doi:10.1080/14786419.2014.947496 |
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