2025-09-16
Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products
Publication
Publication
Natural Product Research , Volume 2025 p. 1- 6
An integrated approach combining biological and chemical investigations were carried out to uncover novel cytotoxic molecules from diverse Papuan marine organisms. Of 386 marine-derived extracts, about 13% (50 extracts) showed significant toxicity in the Artemia salina lethality assay (LC50 ≤ 5 µg/mL). Analysis of the Z-factor and Z’-factor confirmed the excellent quality of the assay (Z = 0.76, Z’ = 0.5). Of the 50 active extracts, seven extracts from Achantostrongylophora ingens, Theonella sp., Ianthella basta, a cyanobacterium, a sponge from family Thorectidae, and a rare Axinella sp. were further evaluated for cytotoxicity against HEK293T, 1H NMR spectral, LC-HR-MS/MS, feature-based molecular networking (FBMN), and chemoinformatics analyses. The chemical analyses revealed the presence of 43 known and 381 putatively new bioactive molecules. The integrated biological and chemistry approach adopted in this study is effective for prioritising important marine extracts with high probability of discovering novel cytotoxic compounds.
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| doi.org/10.1080/14786419.2025.2559778 | |
| Natural Product Research | |
| Organisation | Staff publications |
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Hanif, Novriyandi, Pakan, Jonathan Stefanson, Lisias, Shannon Christela, Sael, Wildan Bachtiar, Santosa, Nurul Fajar, Tyas, Trianda Ayuning, … Tanaka, Junichi. (2025). Integrated biological and chemical investigation of papuan marine organisms for the discovery of potential cytotoxic marine natural products. Natural Product Research, 2025, 1–6. doi:10.1080/14786419.2025.2559778 |
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