A new diterpenoid endoperoxide showing cytotoxicity named amitorin (1) was isolated from an extract of a sponge Halichondria sp. Its structure along with relative stereochemistry was elucidated with spectral analysis and calculation studies. The structure and cytotoxicity (IC50 2.3 µM against NBT-II cells) of the molecule are described herein.

doi.org/10.1246/cl.220371
Chemistry Letters
Staff publications

Wauke, Tsuyoshi, Hanif, Novriyandi, Ohlinger, Sean, de Voogd, N., Kurnianda, Viqqi, Jomori, Takahiro, & Tanaka, Junichi. (2022). Amitorin, a cytotoxic diterpenoid from a sponge Halichondria sp. Chemistry Letters, 51(11), 1080–1082. doi:10.1246/cl.220371