2012-05-24
Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus
Publication
Publication
Bioorganic & Medicinal Chemistry , Volume 20 - Issue 14 p. 4437- 4442
Hyrtioreticulins A–E (1–5) were isolated from the marine sponge Hyrtios reticulatus, along with a known alkaloid, hyrtioerectine B (6). Structural elucidation on the basis of spectral data showed that 1, 2, and 5 are new tetrahydro-β-carboline alkaloids, while 3 and 4 are new azepinoindole-type alkaloids. Hyrtioreticulins A and B (1 and 2) inhibited ubiquitin-activating enzyme (E1) with IC50 values of 0.75 and 11 μg/mL, respectively, measured by their inhibitory abilities against the formation of an E1-ubiquitin intermediate. So far, only five E1 inhibitors, panapophenanthrine, himeic acid A, largazole, and hyrtioreticulins A and B (1 and 2), have been isolated from natural sources and, among them, 1 is the most potent E1 inhibitor.
| Additional Metadata | |
|---|---|
| , , , | |
| doi.org/10.1016/j.bmc.2012.05.044 | |
| Bioorganic & Medicinal Chemistry | |
| Organisation | Staff publications |
|
Yamanokuchi, Rumi, Imada, Kumiko, Miyazaki, Mitsue, Kato, Hikaru, Watanabe, Tadashi, Fujimuro, Masahiro, Saeki, Yasushi, Yoshinaga, Sosuke, Terasawa, Hiroaki, Iwasaki, Noriyuki, Rotinsulu, Henki, Losung, Fitje, Mangindaan, Remy E.P., Namikoshi, Michio, de Voogd, N., Yokosawa, Hideyoshi& Tsukamoto, Sachiko. (2012). Hyrtioreticulins A–E, indole alkaloids inhibiting the ubiquitin-activating enzyme, from the marine sponge Hyrtios reticulatus. Bioorganic & Medicinal Chemistry, 20(14), 4437–4442.https://doi.org/10.1016/j.bmc.2012.05.044 |
|
