A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 μM.

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doi.org/10.3390/md22040171
Marine Drugs

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Staff publications

Oyadomari, Yasumoto, Goto, Yasuyuki, Suganuma, Keisuke, Kawazu, Shin-ichiro, Becking, L., Fusetani, Nobuhiro, & Nakao, Yoichi. (2024). Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica. Marine Drugs, 22(4). doi:10.3390/md22040171