The small genus Tetrameranthus (five species) stands isolated within the Annonaceae. A cladistic analysis was carried out using macromorphological characters in order to find possible apomorphies and to attempt a phylogenetic reconstruction. In the “best” cladograms there appear two subsets, one formed by T. duckei, T. macrocarpus, and T. pachycarpus, the other by T. laomae and T. umbellatus. Both are supported by a number of apomorphic character states. Any other conclusions remain speculative.