The hyphomycete Myriodontium keratinophilum, gen. et sp. nov., is described and illustrated. It was isolated from soil and a preputial swab of a bull. The new taxon is characterized by fertile hyphae consisting of intercalary polyblastic conidiogenous cells and one-celled conidia borne on long denticles. Its relationship to other hyphomycetous genera with solitary blastic conidia is discussed.