The generic differences between Antirhea Comm. ex A.L. de Juss. and Guettardella Benth. in Champ. (Rubiaceae: Guettardeae) are discussed. Antirhea borbonica J.F. Gmel. and A. bifurcata (Desr.) Hook, f., the only Old World species of Antirhea and until now inadequately known are fully described. In Guettardella, 10 new species are proposed and 8 new combinations are made.