The genus Alyxia is revised for Continental Asia and Malesia as the first part of a complete revision of the genus. Intergeneric and infrageneric relationships are discussed, as are the morphological characters for the whole genus. Problematic species and areas in need of further study are highlighted. Keys and descriptions for the species are given. 69 species are recognised of which 12 are newly described. These new species are Alyxia celebica, A. globosa, A. graciliflora, A. kwalotabaa, A. lackii, A. longiloba, A. manusiana, A. minutiflora, A. muguma, A. papuana, A. uniflora and A. vera.