Eleven new species and one new subspecies of Ficus from South America, mainly from the Andean region, are described and illustrated: F. cotopaxiensis, F. ecuadorensis, F. francoae, F. jacobii subsp. mantana, F. loxensis, F. maximoides, F. pastasana, F. quichuana, F. quistocochensis, F. rimacana, F. sumacoana, and F. valaria. Ficus malacocarpa Standl. is reduced to a subspecies of F. popenoei Standl.